Publications by authors named "D Bosco"
Phytoplasmas are phloem-limited plant pathogenic bacteria causing diseases in many plant species. They are transmitted by Hemipteran insect species in a persistent-propagative manner. Phytoplasmas are wall-less, and their membrane proteins are involved in pathogen internalization into host cells.
View Article and Find Full Text PDFRNA interference (RNAi) is double stranded RNA (dsRNA)-based gene silencing mechanism. Exogenous dsRNAs application to crops has raised as a powerful tool to control agricultural pests. In particular, several sap-feeder are important plant pathogens vectors, such as Philaenus spumarius, known as main vector of Xylella fastidiosa (Xf), causal agent of olive quick decline syndrome (OQDS) in southern Italy.
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- TREM2 is a receptor found in microglia, crucial for their functions like proliferation and phagocytosis, and plays a key role in neurodegenerative diseases.
- Research using TREM2 knockout mice in a seizure model showed that lacking TREM2 worsened seizure pathology and increased the frequency of recurrent seizures.
- In humans, lower levels of a microglial phagocytic marker, CD68, were associated with more severe seizure histories, suggesting that TREM2 and microglial phagocytosis are vital in epilepsy development.
Flavescence dorée (FD) is a phytoplasma disease transmitted by insects, causing severe damage to vineyards across Europe. Infected plants cannot be cured and must be removed to prevent further spread. Different grapevine cultivars show varying susceptibility to FD, and some exhibit symptom remission, known as recovery, although the mechanisms behind this are unclear.
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- A 78-year-old man experienced an acute stroke due to a posterior inferior cerebellar artery blockage, resulting in severe vertigo, gait imbalance, and dysphagia.
- Clinical examination revealed complex nystagmus patterns: a right-beating nystagmus in primary gaze and a left-beating nystagmus when looking left, indicating central nervous system involvement.
- Brain imaging confirmed an acute stroke affecting the left medulla and cerebellum, suggesting that damage to specific brain structures can lead to diverse nystagmus presentations associated with central lesions.