Publications by authors named "D Bories"
Article Synopsis
- Several fusion genes linked to leukemia, like BCR::ABL1 and PML::RARA, have targeted therapies that improve outcomes, but relapse still poses a challenge.
- Current myeloid next-generation sequencing (NGS) methods often miss detecting these fusion genes, complicating analysis of disease progression and treatment strategies.
- A new sequencing approach (aCAP-Seq) and bioinformatics tool (HmnFusion) demonstrate high accuracy in detecting these fusions, allowing better understanding of clonal dynamics in leukemia patients and supporting insights into their resistance to treatments.
Objectives: Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities. However, the effect of additional genetic anomalies on the behavior of inv(16) AML is debatable.
View Article and Find Full Text PDFGraft-versus-host disease (GVHD) remains a major clinical drawback of allogeneic hematopoietic stem cell transplantation (HSCT). Here, we investigated how the stress responsive heme catabolizing enzyme heme oxygenase-1 (HO-1, encoded by ) regulates GVHD in response to allogeneic hematopoietic stem cell transplantation in mice and humans. We found that deletion of the allele, specifically in the myeloid compartment of mouse donor bone marrow, promotes the development of aggressive GVHD after allogeneic transplantation.
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