Publications by authors named "D Borden Lacy"
We report on the synthesis and characterization of Mn(III) chloride (MnCl) complexes coordinated with -oxide ylide ligands, namely trimethyl--oxide (MeNO) and pyridine--oxide (PyNO). The compounds are reactive and, while isolable in the solid-state at room temperature, readily decompose into Mn(II). For example, "[MnCl(ONMe)]" decomposes into the 2D polymeric network compound complex salt [Mn(µ-Cl)Mn(µ-ONMe)][Mn(µ-Cl)]·(MeNO·HCl) ().
View Article and Find Full Text PDFArticle Synopsis
- Clostridioides difficile (C. diff) is a germ that causes diarrhea and serious gut problems, especially in hospitals.
- It produces harmful proteins called toxins, including the less understood CDT toxin, which causes inflammation in the body.
- Researchers found that CDT activates certain immune cells in a way that doesn't depend on a specific inflammatory pathway, suggesting its effects may not be as straightforward as previously thought.
This work details the synthesis and characterization of complexes of the form [MnX(PR)] (X = Cl, Br, I), which is a rare type of coordination compound. Prior to this work, the only mode of synthesis was oxidizing mixtures of MnX and PR with dry air, but these procedures give low yields and variable outcomes. By taking advantage of the starting material [MnCl(OPPh)] () and other new strategies, we present robust synthetic protocols for both new and known Mn(III) halido phosphine complexes.
View Article and Find Full Text PDFis a common cause of diarrhea and mortality, especially in immunosuppressed and hospitalized patients. is a toxin-mediated disease, but the host cell receptors for toxin B (TcdB) have only recently been revealed. Emerging data suggest TcdB interacts with receptor tyrosine kinases during infection.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a one-pot method to create a stable molecular complex, [Mn(NO)(OPPh)], which serves as an effective reagent for selective one-electron oxidation (deelectronation).
- The complex boasts a high reduction potential of 1.02 V versus ferrocene, making it one of the strongest readily available redox agents for chemical reactions.
- It is easy to handle, stable in air as a solid, and soluble in common lab solvents, allowing for the synthesis of other manganese complexes with similarly high reduction potentials.