Publications by authors named "D Bonderman"
Background: There is an unmet need for early detection of heart failure decompensation, allowing patients to be managed remotely and avoid hospitalization.
Objectives: The purpose of this study was to compare a strategy utilizing data from a wearable HF sensor for management following a HF hospitalization to usual care.
Methods: Eligible subjects were discharged from the hospital within the previous 10 days and had a HF event in the previous 6 months.
Article Synopsis
- Intracardiac thrombosis is frequent in patients with transthyretin amyloid cardiomyopathy (ATTR-CM), leading to potential risks like thromboembolic events, but the impact on brain health remains unclear.
- A study involving 32 ATTR-CM patients showed significant findings using cerebral magnetic resonance imaging (cMRI), indicating they had more territorial infarcts, microbleeds, and Virchow-Robin spaces compared to matched controls.
- The results suggest that even asymptomatic ATTR-CM patients might benefit from routine cMRI screening and consideration for anticoagulation therapy due to underlying cerebral vessel disease.
Aims: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) experience reduced functional capacity. We evaluated changes in functional capacity over extensive follow-up using cardiopulmonary exercise testing (CPX).
Methods: ATTR-CM patients underwent CPX and blood testing at baseline, first [V1, 8 (6-10) months] and second follow-up (V2) at 35 (26-41) months after start of disease-specific therapy.
Background: Despite known clinical benefits, guideline-recommended heart rate (HR) control is not achieved for a significant proportion of patients with HF with reduced ejection fraction. The wearable cardioverter-defibrillator (WCD) provides continuous HR monitoring and alerts that could aid medication titration.
Objective: This study sought to evaluate sex differences in achieving guideline-recommended HR control during a period of WCD use.
Aims: Transthyretin 'wild-type' amyloid cardiomyopathy (ATTRwt-CM) is a differential diagnosis of heart failure with preserved ejection fraction (HFpEF). The clinical work-up for ATTRwt-CM is challenging. Considering a combination of clinical variables specific for ATTRwt-CM might aid in identifying patients at risk.
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