Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues.

The chemical structure of a delivery nanovehicle plays a pivotal role in determining the efficiency of drug delivery within the body. Leveraging the unique architecture of bottlebrush (BB) polymers-characterized by variations in backbone length, grafting density, and self-assembly morphology-offers a novel approach to understanding the influence of structural properties on biological behavior. In this study, developed a drug delivery system based on core-shell BB polymers synthesized using a "grafting-from" strategy.

Quantifying the chemical activity of cavitation bubbles in a cluster.

Acoustic cavitation bubbles drive chemical processes through their dynamic lifecycle in liquids. These bubbles are abundant within sonoreactors, where their behavior becomes complex within clusters. This study quantifies their chemical effects within well-defined clusters using a new laser-based method.

Ultrasound and sonochemistry enhance education outcomes: From fundamentals and applied research to entrepreneurial potential.

With this manuscript we aim to initiate a discussion specific to educational actions around ultrasonics sonochemistry. The importance of these actions does not just derive from a mere pedagogical significance, but they can be an exceptional tool for illustrating various concepts in other disciplines, such as process intensification and microfluidics. Sonochemistry is currently a far-reaching discipline extending across different scales of applicability, from the fundamental physics of tiny bubbles and molecules, up to process plants.

CT-FEM of the human thorax: Frequency response function and 3D harmonic analysis at resonance.

Background And Objective: High-frequency chest wall compression (HFCC) therapy by airway clearance devices (ACDs) acts on the rheological properties of bronchial mucus to assist in clearing pulmonary secretions. Investigating low-frequency vibrations on the human thorax through numerical simulations is critical to ensure consistency and repeatability of studies by reducing extreme variability in body measurements across individuals. This study aims to present the numerical investigation of the harmonic acoustic excitation of ACDs on the human chest as a gentle and effective HFCC therapy.

Carbon capture, utilization and sequestration systems design and operation optimization: Assessment and perspectives of artificial intelligence opportunities.

Carbon capture, utilization, and sequestration (CCUS) is a promising solution to decarbonize the energy and industrial sectors to mitigate climate change. An integrated assessment of technological options is required for the effective deployment of CCUS large-scale infrastructure between CO production and utilization/sequestration nodes. However, developing cost-effective strategies from engineering and operation perspectives to implement CCUS is challenging.