Publications by authors named "D Bodmer"
Article Synopsis
- Preserving hair cells is essential for hearing, as their damage is linked to permanent hearing loss and is often caused by inflammation and oxidative stress.
- Mitochondrial-derived peptides (MDPs), especially Humanin (HN) and its synthetic variant HN S14G (HNG), have shown protective effects on hair cells, with HNG being more potent than natural HN.
- Research revealed that HNG and the lesser-known peptide SHLP3 can reduce hair cell loss caused by gentamicin, primarily by regulating key proteins and decreasing oxidative stress and inflammation, suggesting potential therapeutic uses for these peptides in combating hearing loss.
Article Synopsis
- The blood-labyrinth barrier (BLB) is crucial for maintaining the ionic balance in the inner ear and preventing harmful substances from entering.
- Recent studies have shown that dysregulation of BLB permeability is linked to various auditory issues, such as acoustic trauma and autoimmune diseases.
- This study found that neutrophil extracellular traps (NETs) affect endothelial cells in the BLB, leading to increased permeability and changes in cell structure, suggesting a need for further research on NETs' role in auditory disorders.
Article Synopsis
- * Early detection and appropriate diagnostic measures are essential for initiating effective treatments and avoiding long-term disabilities.
- * Treatment options primarily involve surgery for pinna malformations, with tissue engineering expected to play a key role in the future; auditory rehabilitation ranges from hearing aids to more invasive implants for enhancing hearing and preventing complications.
Objective: The modern management of patients with Koos grade IV vestibular schwannomas (VSs) aims at functional preservation and long-term tumor control. Gross-total resection (GTR) leads to optimal tumor control but frequently also results in permanent facial nerve (FN) palsy. Subtotal resection (STR) or near-total resection (NTR) followed by a wait-and-scan protocol and second-line radiation therapy (RT) in case of progressive residuals yields excellent tumor control rates with less permanent morbidity.
View Article and Find Full Text PDFCongenital malformations of the pinna and aural atresia can result in major aesthetic and functional deficits. Knowledge about embryologic developments and established classification systems is an essential requirement when dealing with affected patients. Early detection of deficiencies and introduction of appropriate diagnostic measures is vital to initiate adequate therapies and prevent long-term disabilities.
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