Publications by authors named "D Blaydon"
Article Synopsis
- Survival rates for esophageal squamous cell carcinoma (ESCC) are low due to late diagnosis, prompting research into early molecular changes that could aid in earlier detection.
- The study examined esophageal biopsies from individuals with Tylosis with esophageal cancer (TOC), a syndrome linked to higher ESCC risk, identifying significant transcriptional changes that were also seen in ESCC.
- Results indicated that these early changes may be crucial in understanding how sporadic ESCC develops and highlighted specific upregulated genes like Keratin 17 that could serve as potential biomarkers.
Article Synopsis
- Congenital ichthyosis (CI) is a rare hereditary skin disorder characterized by symptoms like scaling and inflammation, prompting research into the skin microbiome's role in these conditions.
- A study involving 36 CI patients and 15 controls revealed novel and recurrent pathogenic variants, along with distinct microbial profiles showing reduced beneficial microbes and increased harmful ones, which correlate with heightened inflammation.
- The findings provide insights into the microbiological and immune factors affecting CI, laying the groundwork for better treatment options for patients.
iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signaling; they function primarily by recognizing transmembrane domains of their clients. Here, we report a mechanistically distinct nuclear function of iRhoms, showing that both human and mouse iRhom2 are non-canonical substrates of signal peptidase complex (SPC), the protease that removes signal peptides from secreted proteins. Cleavage of iRhom2 generates an N-terminal fragment that enters the nucleus and modifies the transcriptome, in part by binding C-terminal binding proteins (CtBPs).
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- The study investigates differences in immune cell signatures and sensory markers in various reflux disease phenotypes compared to healthy subjects.
- Thirty-seven patients were categorized into four groups (ERD, NERD, FH, and BO) and their tissue samples analyzed through mRNA sequencing and immunofluorescent staining.
- Results showed increased mast cell abundance and decreased dendritic cell infiltration in GERD patients, along with higher nerve growth factor expression in mast cells, indicating potential mechanisms for esophageal sensitivity and immune response development.