Publications by authors named "D Billmire"
Germ cell tumors (GCT) are a complex, heterogeneous collection of tumors that may present in either gonadal or extragonadal sites. They consist of a variety of benign and malignant histologies that can occur at several locations throughout the body. An important component of treatment is surgical resection, and while the key components of resection are site specific, the universal goals of GCT resection include the complete resection of tumor without violating the tumor capsule, while preserving function of surrounding organs, minimizing morbidity, and assessing for regional spread.
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- Women aged 40 years and older diagnosed with malignant ovarian germ cell tumors experience poorer outcomes compared to younger patients (15-39 years), reflecting higher risks and severity of their conditions.
- The study utilized the National Cancer Database from 2004-2016 to analyze care patterns and survival rates across different age groups, focusing on four common tumor types.
- Results indicated older women were more likely to face additional health issues, advanced disease stages, and less effective treatments, contributing to a significantly higher risk of death from their diagnosis.
Objective: Sertoli-Leydig cell tumors (SLCTs) are rare sex cord-stromal tumors, representing <0.5% of all ovarian tumors. We sought to describe prognostic factors, treatment and outcomes for individuals with ovarian SLCT.
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- Ovarian Sertoli cell tumors are rare sex cord stromal tumors, especially in prepubertal children, and this case involves a girl initially misdiagnosed with McCune-Albright syndrome.
- The 2.5-year-old patient presented with early breast development and vaginal bleeding, with diagnostic tests showing elevated estrogen levels and advanced bone age, ultimately leading to the discovery of an ovarian tumor.
- Pathology confirmed the tumor as a lipid-rich Sertoli cell tumor, and genetic testing revealed a pathogenic variant associated with Peutz-Jeghers syndrome, making her the youngest reported case of precocious puberty caused by this specific tumor linked to PJS.
Ovarian immature teratoma (IT) is a rare neoplasm comprising ∼3% of ovarian cancers, occurring primarily in young females. Management presents several challenges, including those with elevated serum alpha-fetoprotein, potential confusion regarding pathology interpretation, and paucity of data to support decision-making. MaGIC (https://magicconsortium.
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