Publications by authors named "D Bharadwaj"
Article Synopsis
- - This systematic review evaluated the effectiveness of three external stimulation techniques—electrical stimulation (ES), optogenetic stimulation (OS), and magnetic stimulation (MS)—for promoting peripheral nerve regeneration (PNR) following injuries, using data from studies published between 2018 and 2023.
- - A total of 19 studies were reviewed, revealing that while ES generally improved recovery across measures, high-frequency repetitive magnetic stimulation (HFr-MS) showed accelerated nerve repair, and OS was noted for better functional recovery outcomes.
- - The review highlights the need for standardized testing methods due to limitations in the available data and varied evaluation techniques, suggesting that these external stimulations could significantly enhance recovery for patients with nerve injuries.
Clinical biomarkers such as fasting glucose, HbA1c, and fasting insulin, which gauge glycemic status in the body, are highly influenced by diet. Indians are genetically predisposed to type 2 diabetes and their carbohydrate-centric diet further elevates the disease risk. Despite the combined influence of genetic and environmental risk factors, Indians have been inadequately explored in the studies of glycemic traits.
View Article and Find Full Text PDFTumor microenvironment: A playground for cells from multiple diverse origins.
Biochim Biophys Acta Rev Cancer
September 2024
Tumor microenvironment is formed by various cellular and non-cellular components which interact with one another and form a complex network of interactions. Some of these cellular components also attain a secretory phenotype and release growth factors, cytokines, chemokines etc. in the surroundings which are capable of inducing even greater number of signalling networks.
View Article and Find Full Text PDFThe complex web of obesity: from genetics to precision medicine.
Expert Rev Endocrinol Metab
September 2024
Introduction: Obesity is a growing public health concern affecting both children and adults. Since it involves both genetic and environmental components, the management of obesity requires both, an understanding of the underlying genetics and changes in lifestyle. The knowledge of obesity genetics will enable the possibility of precision medicine in anti-obesity medications.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes (T2D) is a complex disease influenced by various genetic factors and molecular mechanisms that vary by cell type and ancestry.
- In a large study involving over 2.5 million individuals, researchers identified 1,289 significant genetic associations linked to T2D, including 145 new loci not previously reported.
- The study categorized T2D signals into eight distinct clusters based on their connections to cardiometabolic traits and showed that these genetic profiles are linked to vascular complications, emphasizing the role of obesity-related processes across different ancestry groups.