Publications by authors named "D Bettelheim"
Background: Intrauterine transfusions (IUTs) are a life-saving treatment for fetal anemia. However, with each transfusion, iron bypasses uptake regulation through the placenta and accumulates in fetal organs. Unlike other imaging modalities, fetal magnetic resonance imaging (MRI) is capable of non-invasively assessing fetal liver disease and/or organ iron overload.
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- Current standard genetic testing methods struggle to provide detailed information on duplications and balanced structural variants (SV), which can be crucial for clinical assessment.
- A retrospective study from 2023 examined cases where SVs detected by standard methods were further analyzed using optical genome mapping (OGM), revealing that OGM successfully resolved six out of seven cases.
- The study concludes that OGM is a valuable tool for characterizing SVs, providing essential information in certain clinical situations, particularly in prenatal cases or when family analysis is not feasible.
Synthetic MRI and MR Fingerprinting-Derived Relaxometry of Antenatal Human Brainstem Myelination: A Postmortem-Based Quantitative Imaging Study.
AJNR Am J Neuroradiol
September 2024
Background And Purpose: The radiologic evaluation of ongoing myelination is currently limited prenatally. Novel quantitative MR imaging modalities provide relaxometric properties that are linked to myelinogenesis. In this retrospective postmortem imaging study, the capability of Synthetic MR imaging and MR fingerprinting-derived relaxometry for tracking fetal myelin development was investigated.
View Article and Find Full Text PDFFemur development in fetal growth restriction as observed on prenatal magnetic resonance imaging.
Ultrasound Obstet Gynecol
May 2023
Objective: To investigate human femur development in fetal growth restriction (FGR) by analyzing femur morphometrics and distal epimetaphyseal features on prenatal magnetic resonance imaging (MRI).
Methods: This was a retrospective study of 111 fetuses (mean gestational age (GA), 27 + 2 weeks (range, 19-35 weeks)) with FGR associated with placental insufficiency without other major abnormalities and 111 GA-matched normal controls. On 1.
In this study we compare temporal lobe (TL) signal intensity (SI) profiles, along with the average thicknesses of the transient zones obtained from postmortem MRI (pMRI) scans and corresponding histological slices, to the frontal lobe (FL) SI and zone thicknesses, in normal fetal brains. The purpose was to assess the synchronization of the corticogenetic processes in different brain lobes. Nine postmortem human fetal brains without cerebral pathologies, from 19 to 24 weeks of gestation (GW) were analyzed on T2-weighted 3T pMRI, at the coronal level of the thalamus and basal ganglia.
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