Publications by authors named "D Bettega"
Article Synopsis
- * A multicenter study assessed TAS-102's effectiveness and safety in 160 pretreated mCRC patients, including a significant number of elderly patients and those with other health conditions.
- * Results showed a median overall survival of 8 months and no significant age-related decrease in treatment effectiveness, indicating TAS-102 is safe and effective even for older patients.
Article Synopsis
- The study investigates how proton therapy combined with hyperthermia using magnetic nanoparticles affects BxPC3 pancreatic cancer cells, with a focus on cellular responses and survival rates.
- Findings reveal that this combination treatment significantly reduces cell survival compared to proton therapy alone, indicating a possible new effective therapy for pancreatic tumors.
- Additionally, the presence of magnetic nanoparticles enhances radiosensitization and increases reactive oxygen species production, which contributes to DNA damage and cell death, paving the way for clinical application of this combined therapy.
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment of pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0-2 Gy for carbon ions and 0-7 Gy for 6 MV photons. Hyperthermia is realized via a standard heating bath, assisted by magnetic fluid hyperthermia (MFH) that utilizes magnetic nanoparticles (MNPs) exposed to an alternating magnetic field of amplitude 19.
View Article and Find Full Text PDFCurrently we observe a gap between theory and practices of patient engagement. If both scholars and health practitioners do agree on the urgency to realize patient engagement, no shared guidelines exist so far to orient clinical practice. Despite a supportive policy context, progress to achieve greater patient engagement is patchy and slow and often concentrated at the level of policy regulation without dialoguing with practitioners from the clinical field as well as patients and families.
View Article and Find Full Text PDFProduction of photonuclear particles in a tissue-equivalent medium has been calculated for linacs at 6, 10 and 15 MV from Varian TrueBeam. Based on the knowledge of bremsstrahlung fluence spectra and linac photon beam parameters, numerical integration was performed on the cross sections for photoparticle production of the constituent elements of tissue (2H,12C,13C,16O,17O,18O,14N,15N). At 15 MV, at the depth of photon maximum dose, the total absorbed dose due to neutrons, protons, alphas and residual nuclei from photon reactions in tissue (5.
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