Publications by authors named "D Bespiatykh"
and its bacteriophages are among the most studied model microorganisms. Bacteriophages for various strains can typically be easily isolated from environmental sources, and many of these viruses can be harnessed to combat infections in humans and animals. However, some relatively rare strains pose significant challenges in finding suitable phages.
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- The study focuses on how gut microbiota, particularly commensal bacteria like lactobacilli, interact with the host immune system's cytokines, which are critical in managing inflammation and gut health.
- Using next-generation RNA sequencing, researchers examined the transcriptional responses of lactobacillus strains K32 and R19-3 to various cytokines, revealing significant changes in gene expression linked to metabolism and stress response, especially upon exposure to IL-8 and IL-10.
- The findings highlight a complex adaptation mechanism where these bacteria adjust their gene expression in response to inflammatory signals, paving the way for potential probiotic therapies for conditions like inflammatory bowel disease (IBD).
In the context of the antimicrobial therapy crisis, the significance of studying and implementing alternative treatment methods, particularly phage therapy, is increasingly evident. This study aimed to investigate the resistance of clinical Staphylococcus aureus ST239 strains to Herelleviridae phages through comparative genomics, transcriptomics, and proteomics. Analysis of resistant and sensitive S.
View Article and Find Full Text PDFThe issue of antibiotic resistance in healthcare worldwide has led to a pressing need to explore and develop alternative approaches to combat infectious diseases. Among these methods, phage therapy has emerged as a potential solution to tackle this growing challenge. Virulent phages of the family, known for their ability to cause lysis of , a clinically significant pathogen frequently associated with multidrug resistance, have proven to be one of the most effective viruses utilized in phage therapy.
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- The study focuses on the Mycobacterium tuberculosis Beijing 14717-15-cluster, which is a multidrug-resistant and hypervirulent strain found mainly in the Far Eastern region of Russia.
- Researchers collected and analyzed M. tuberculosis DNA from worldwide locations between 1996 and 2020, developing a PCR assay to identify specific mutations related to this deadly strain.
- Phylogenomic analysis confirmed the strain's prevalence in Asian Russia and highlighted unique mutations that could enhance its pathogenicity, suggesting the need for further research on these mutations' biological effects.