Publications by authors named "D Bernhardt"
Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site.
View Article and Find Full Text PDFBackground: Post-Therapy-Pneumonitis (PTP) is a critical side effect of both, thoracic radio(chemo)therapy (R(C)T) and immune checkpoint inhibition (ICI). However, disease characteristics and patient-specific risk factors of PTP after combined R(C)T + ICI are less understood. Given that RT-triggered PTP is strongly dependent on the volume and dose of RT [1], driven by inflammatory mechanisms, we hypothesize that combination therapy of R(C)T with ICI influences the dose-volume-effect correlation for PTP.
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- Randomized studies suggest that (ultra-)hypofractionation is just as effective as a traditional 5-week radiation schedule for treating postoperative breast cancer, but there's limited data on its long-term impact on secondary cancers.
- A study involving 20 breast cancer patients examined different radiation schedules and found that (ultra-)hypofractionation significantly reduced the risk of secondary malignancies like lung cancer, contralateral breast cancer, and soft tissue sarcoma.
- The results indicated that using (ultra-)hypofractionation could lower the risk of developing secondary malignancies more than conventional scheduling, with varying effects based on the radiation technique (3D-CRT vs. VMAT).
Background: Stereotactic Radiosurgery (SRS) is an emerging alternative to whole-brain radiotherapy (WBRT) for treating multiple brain metastases (BM), reducing toxicity and improving tumor control. The CYBER-SPACE trial compared SRS based on either SPACE or MPRAGE MRI sequence for avoiding or delaying WBRT in patients with 1-10 BM.
Methods: Patients with 1-10 untreated BM were randomized 1:1 to receive SRS of all lesions based on either SPACE or MPRAGE MRI sequences.
Article Synopsis
- Skin inflammation and conditions like moist epitheliolysis and edema are common acute side effects of breast radiotherapy (RT).
- The study aimed to evaluate the effectiveness of tissue-derived radiomics features compared to total breast volume (TBV) in predicting these side effects.
- The best predictive model used a LASSO classifier based on TBV, achieving an AUROC of 0.74, similar to the AUROC of 0.75 for TBV alone, with mammary tissue showing greater predictive power than glandular tissue.