Publications by authors named "D Berk"
Safety and efficacy of roflumilast cream 0.15% for atopic dermatitis (AD) were demonstrated in two 4-week phase 3 trials. Evaluate long-term safety, tolerability, and efficacy of roflumilast cream 0.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness of a new topical roflumilast cream vehicle compared to a popular ceramide-containing moisturizer in improving skin barrier function for patients with mild asteatotic eczema.
- Over 17 days, 40 patients applied the roflumilast vehicle on one leg and the moisturizer on the other, measuring transepidermal water loss (TEWL) and skin hydration at various intervals.
- Results showed both treatments effectively improved skin hydration, with no significant differences in performance after day 1, indicating that the new vehicle is comparable to the established moisturizer.
Article Synopsis
- Safe and effective long-term topical treatments for atopic dermatitis (AD) are limited, leading to low adherence rates among patients.
- The study aimed to assess the efficacy and safety of once-daily roflumilast cream (0.15%) compared to a vehicle cream in patients aged 6 and older with mild to moderate AD across two phase 3 trials.
- Results showed that a significantly higher percentage of patients using roflumilast achieved treatment success and a notable reduction in eczema severity compared to those using the vehicle cream.
Prymnesins, produced by the haptophyte Prymnesium parvum, are considered responsible for fish kills when this species blooms. Although their toxic mechanism is not fully understood, membrane disruptive properties have been ascribed to A-type prymnesins. Currently it is suggested that pore-formation is the underlying cause of cell disruption.
View Article and Find Full Text PDFObjective: To evaluate the role of Extended Scope (ES) audiologists in managing adult Ear Nose and Throat (ENT)/Otology waitlists and analyse patient re-presentation rate to the ENT service within 12 months of being discharged from the clinic.
Design: A retrospective cohort study assessing the efficacy of ES audiologists, measuring the discharge rate from ENT waitlists, the rate of escalation to ENT care, and the rate and reasons for any re-presentations to care.
Study Sample: 394 adult patients.