STUDY OF THE BIOACTIVE COMPOUNDS CONTENT IN THE FLOWERS OF POLIANTHES TUBEROSA L. INTRODUCED BY GREEN TECHNOLOGIES.

The content of bioactive compounds of perennial, fragrant species of tuberose or Polianthes tuberosa L. representing the genus Polianthes L., asparagus (Asparagaceae Juss) family, highly decorative and widely accepted in the perfumery industry and extremely sensitive to environmental conditions, native to Mexico, was studied based on of raw materials of the flowers of the said plant introduced to five different locations of the BBG with various exposition and soil content by green technologies.

FORMULATION THERMORESPONSIVE NANOCOMPOSITE HYDROGELWITH EMBEDDED PLGA NANOPARTICLES CONTAINING CYTOTOXIC AGENT.

The aim of the study was to develop and characterize the nanocomposite in-situ hydrogel as local drug delivery system of cytotoxic agent. In-situ hydrogel consisting of 15% thermosensitive (Poloxamer 407) and 1% mucoadhesive (sodium alginate) polymers was selected as the optimal formulation by the conducted studies. The influence of nanoparticle concentration on gelation time and temperature has been experimentally established.

BIOPHARMACEUTICAL UNDERSTANDING OF FORMULATION PREPARATION VARIABILITY OF PLGA NANOPARTICLES LOADED WITH ERYSIMUM EXTRACT.

The purpose of this study was to evaluate effect of process and formulation variables on the preparation of Erysimum extract loaded PLGA nanoparticles. The influence of the various biopharmaceutical factors such as type of organic solvent, type and concentration of surfactant, polymer concentration in the organic phase, ratio of organic phase and water phase were studied. Modified emulsification solvent evaporation method was used for preparation of nanoparticles.

; INTRODUCTION OF AROMATIC PLANTS IN THE BATUMI BOTANICAL GARDEN AND THEIR RESEARCH FOR THE CONTENT OF BIOLOGICALLY ACTIVE COMPOUNDS.

The research objectives were to study the introduction process of different aromatic and spice plants in the Batumi Botanical Garden and the content of bioactive compounds in aromatic plants introduced and grown in the soil and climatic conditions of the garden.; Among the aromatic plants introduced to the BBG by the authors, the following species are having full vegetative and generative development in the open ground:Cuminum cyminum L.; Polianthes tuberosa L.

FORMULATION OF BIODEGRADABLE POLYMERIC NANOPARTICLES CONTAINING CYTOTOXIC SUBSTANCE OF PLANT ORIGIN.

Formulation of novel drug delivery system is one of the approaches for improvement of pharmacological activity of drugs. This implies encapsulation of the API into the biocompatible polymeric material. Objective of the research was formulation of biodegradable amino acid based polyesteramide nanoparticles composing cytotoxic substance of plant origin.