Publications by authors named "D Bendetowicz"
Article Synopsis
- The review outlines neuroprotection trials for multiple system atrophy (MSA), a serious neurodegenerative disease, and discusses important factors for conducting successful clinical trials, such as diagnosis and study design.
- Over 30 compounds have been evaluated in MSA trials, but only two have been successful in meeting their primary endpoint, indicating a need for better understanding of the disease.
- Current trials focus on targeting α-synuclein, a key feature of MSA, and emphasize the necessity of improving disease models, clinical measurement tools, and biomarker research to enhance future trial outcomes.
Article Synopsis
- * Individual preferences for choice vary, with some people showing sensitivity to potential negative outcomes and adjusting their choices based on perceived risk.
- * The relationship between choice preference and extrinsic factors like reward probability and control over outcomes suggests that both psychological and contextual elements influence decision-making.
Background: APP duplication is a rare genetic cause of Alzheimer disease and cerebral amyloid angiopathy (CAA). We aimed to evaluate the phenotypes of APP duplications carriers.
Methods: Clinical, radiological, and neuropathological features of 43 APP duplication carriers from 24 French families were retrospectively analyzed, and MRI features and cerebrospinal fluid (CSF) biomarkers were compared to 40 APP-negative CAA controls.
Body-worn sensors (BWS) could provide valuable information in the management of Parkinson's disease and support therapeutic decisions based on objective monitoring. To study this pivotal step and better understand how relevant information is extracted from BWS results and translated into treatment adaptation, eight neurologists examined eight virtual cases composed of basic patient profiles and their BWS monitoring results. Sixty-four interpretations of monitoring results and the subsequent therapeutic decisions were collected.
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