Publications by authors named "D Benarroch"
Inappropriate and disproportionate use of antibiotics have led to a rapid increase in antibacterial resistance. Therefore, alternative antibacterial strategies and solutions are sought to overcome any form of resistance to effectively treat and/or prevent the spread of infections. In this study, we report an eco-friendly and scalable approach to produce highly antibacterial CuOZnO nanocomposite and its inclusion in medical devices and acrylic paint.
View Article and Find Full Text PDFThe 2,2,7-trimethylguanosine caps of eukaryal snRNAs and snoRNA are formed by the enzyme Tgs1, which catalyzes sequential guanine-N2 methylations of m(7)G caps. Atypically, in the divergent unicellular eukaryote Trichomonas vaginalis, spliceosomal snRNAs lack a guanosine cap and the recombinant T. vaginalis trimethylguanosine synthase (TvTgs) produces only m(2,7)G in vitro.
View Article and Find Full Text PDFHuman telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5' exonuclease activity of its binding partner, Apollo, a member of the metallo-beta-lactamase family that is required for telomere integrity during S phase. TRF2 and Apollo also suppress damage to engineered interstitial telomere repeat tracts that were inserted far away from chromosome ends.
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- The Tgs proteins are enzymes involved in methylating specific RNA nucleotides, particularly in forming the TMG RNA cap.
- Human Tgs1 can perform two distinct methylation steps on the 7-methylguanosine (m(7)G) cap to create a fully modified TMG cap, while Giardia's Tgs can only create a dimethylguanosine cap and cannot convert it to TMG.
- The Mimivirus Tgs shares some traits with Giardia's Tgs but can perform a single methylation step without the need for prior modifications, illustrating diverse capabilities within the Tgs enzyme family.
A 2,2,7-trimethylguanosine (TMG) cap is a signature feature of eukaryal snRNAs, telomerase RNAs, and trans-spliced nematode mRNAs. TMG and 2,7-dimethylguanosine (DMG) caps are also present on mRNAs of two species of alphaviruses (positive strand RNA viruses of the Togaviridae family). It is presently not known how viral mRNAs might acquire a hypermethylated cap.
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