Structure Evolution of Ge-Doped CaTiO (CTG) at High Pressure: Search for the First 2:4 Locked-Tilt Perovskite by Synchrotron X-ray Diffraction and DFT Calculations.

This research investigates the high-pressure behavior of the Ca(TiGe)O perovskite, a candidate of the locked-tilt perovskite family (orthorhombic compounds characterized by the absence of changes in the octahedral tilt and volume reduction under pressure controlled solely by isotropic compression). The study combines experimental high-pressure synchrotron diffraction data with density functional theory (DFT) calculations, complemented by the X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS), to understand the structural evolution of the perovskite under pressure. The results show that CTG undergoes nearly isotropic compression with the same compressibility along all three unit-cell axes (i.

Clinical outcomes after CPX-351 in patients with high-risk acute myeloid leukemia: A comparison with a matched cohort from the Spanish PETHEMA registry.

Background: CPX-351 is approved for the treatment of therapy related acute myeloid leukemia (t-AML) and AML with myelodysplastic related changes (MRC-AML). The benefits of this treatment over standard chemotherapy has not been addressed in well matched cohorts of real-life patients.

Methods: Retrospective analysis of AML patients treated with CPX-351 as per routine practice.

Impact of graphene oxide lateral dimensions on the properties of methacrylated gelatin nanocomposite hydrogels.

The size and shape of nanoparticles have a profound effect on the properties of nanocomposites. For instance, the lateral dimensions of graphene oxide (GO) platelets affect several properties, including their antibacterial and pharmacokinetic functions. However, the impact of lateral dimensions has been poorly studied in nanocomposites, and their effect on hydrogels is still unknown.

MgAlSiO jeffbenite inclusion in super-deep diamonds is thermodynamically stable at very shallow Earth's depths.

Jeffbenite (having the same chemical composition of pyrope, ~ MgAlSiO, and also known as TAPP phase) is a mineral inclusion only found in diamonds formed between about 300 and 1000 km depth) and is considered a stable phase in the transition zone (410-660 km depth) and/or in the shallowest regions of the lower mantle (around 660-700 km depth). This rare and enigmatic mineral is considered to be a pressure marker for super-deep diamonds and therefore it has a key role in super-deep diamond research. However, the pressure-temperature stability fields for MgAlSiO jeffbenite is unknown and its actual formation conditions remain unexplored.