Publications by authors named "D Beckman"
Introduction: The understanding of the pathological events in Alzheimer's disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic.
Methods: To examine how tau pathology can develop in the primate brain, we injected 12 macaques with a dual tau mutation (P301L/S320F) into the entorhinal cortex (ERC). An investigation was performed using high-resolution microscopy, magnetic resonance imaging (MRI), positron emission tomography (PET), and fluid biomarkers to determine the temporal progression of the pathology 3 and 6 months after the injection.
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like receptor family in humans play a central role in NK cell immunity through recognition of MHC class I and related molecules. Functionally, these receptor families are involved in licensing and rejection of MHC-I-deficient cells through missing-self.
View Article and Find Full Text PDFRelationships Among Mode of Birth, Onset of Labor, and Bishop Score.
J Obstet Gynecol Neonatal Nurs
September 2024
Objective: To investigate mode of birth in relation to onset of labor and Bishop score.
Design: Retrospective observational cohort design.
Setting: A 434-bed Magnet redesignated community hospital.
Article Synopsis
- CD4+ T cells in the brain help maintain immune balance, but their specific roles and abilities are still being studied.
- Using various analysis techniques, researchers discovered a unique group of CD4+ T cells that share characteristics with central memory cells found in lymph nodes, showing they can effectively respond to immune challenges.
- The study also found that when TCM cells are trapped in lymph nodes, they decrease in the brain's cerebrospinal fluid, indicating their importance in monitoring brain immune health, especially during chronic infections.