Publications by authors named "D Baulcombe"

Potato virus X (PVX) vectors expressing the Arabidopsis thaliana FLOWERING LOCUS T (FT) or tomato FT ortholog SINGLE-FLOWER TRUSS (SFT) shortened the generation time in tomato due to accelerated tomato flowering and ripening by 14-21 d, and caused a 2-3-fold increase in the number of flowers and fruits, compared with non-infected or empty vector-infected plants. The Arabidopsis FT was more effective than the tomato orthologue SFT and there was no alteration of the flower or fruit morphology. The virus was not transmitted to the next generation; therefore viral vectors with expression of a heterologous FT will be a useful approach to speed breeding in tomato and other species.

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An RNA World.

Annu Rev Plant Biol

May 2023

My research career started with an ambition to work out how genes are regulated in plants. I tried out various experimental systems-artichoke tissue culture in Edinburgh; soybean root nodules in Montreal; soybean hypocotyls in Athens, Georgia; and cereal aleurones in Cambridge-but eventually I discovered plant viruses. Viral satellite RNAs were my first interest, but I then explored transgenic and natural disease resistance and was led by curiosity into topics beyond virology, including RNA silencing, epigenetics, and more recently, genome evolution.

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Article Synopsis
  • RNA silencing helps plants fight off viruses by using small pieces of RNA to target and stop the virus's genetic material.
  • Some viruses have tricks to avoid being attacked by this RNA silencing system.
  • Researchers are exploring how RNA silencing also helps plants defend against other types of pathogens and how it interacts with different immune responses in plants.
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Article Synopsis
  • Plants have a special way of fighting viruses using tiny pieces of RNA that help cut up the virus's genetic material.
  • Some plant viruses can defend themselves by producing proteins that stop this RNA fight.
  • Scientists are exploring ways to use this method to protect crops and even help animals and people against viruses, but there are challenges in getting the right pieces of RNA into the right cells.
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Background: Hybridization is associated with the activation of transposable elements and changes in the patterns of gene expression leading to phenotypic changes. However, the underlying mechanisms are not well understood.

Results: Here, we describe the changes to the gene expression in interspecific Solanum hybrids that are associated with small RNAs derived from endogenous (para)retroviruses (EPRV).

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