High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study.

Colorectal cancer (CRC) is a major public health concern and identifying prognostic molecular biomarkers can help stratify patients based on risk profiles, thus enabling personalized medicine. Epitranscriptomic modifications play a relevant role in controlling gene expression, N6-methyladenosine (m6A) regulators play crucial roles in cancer progression, but their clinical significance in CRC cancer has thus far not been elucidated. Thus, we aimed to examine by immunohistochemical techniques and RT-qPCR, protein levels and RNAs expression of m6A writers (METTL3, WTAP) and eraser (FTO) in a cohort of 10 patients affected by CRC.

Enteric methane emissions from zebu cattle are influenced by seasonal variations in rangeland fodder quality and intake.

Rangeland fodder resources used to feed ruminants in the Sahel decline considerably in both quantity and quality from the wet to dry seasons. While it is widely assumed worldwide that this seasonality of fodder supply impacts intake levels and therefore enteric methane (eCH) emissions, there are very few references based on in vivo measurements of eCH in this region. The purpose of this study was to test the assumption that the seasonality of fodder supply impacts intake levels and consequently eCH in ruminants.

Supplementing zebu cattle with crop co-products helps to reduce enteric emissions in West Africa.

In Africa, a wide variety of diets (forage + crop co-products or other agricultural by-products) is being used by livestock farmers in different production systems to adapt to climate change. This study aimed to assess the performance of various local feeding strategies on Sudanese Fulani zebu cattle. Two experiments were carried out on 10 steers aged initially 33 months (142 kg body weight - BW).

Linkages between traits and decomposition of weed communities along a soil management and pedoclimate gradient in Mediterranean vineyards.

Background And Aims: Decomposition is a major ecosystem process which improves soil quality. Despite that, only a few studies have analysed decomposition in an agricultural context, while most agrosystems (e.g.

Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma.

Background: The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identified in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored.