Publications by authors named "D Bartosova"

Background: Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism. The objective of this study is to present diagnostic pitfalls and long time follow-up data in Wilson disease.

Patients/methods: We studied 21 WD patients and 14 heterozygote carriers aged 2-43 years, retrospectively.

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Objective: To evaluate the role of genetic polymorphisms of the bactericidal permeability increasing protein (BPI) in pediatric patients with sepsis.

Design: Prospective, single-center, case-control study at the pediatric intensive care unit (PICU) of a university hospital.

Patients: 345 consecutive pediatric patients admitted to the PICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ distress syndrome (MODS).

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A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care unit with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ distress syndrome (MODS) were studied together with 644 healthy controls.

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At present, Bartonella species are increasingly important as infectious agents in both animals and humans. Bartonella henselae, the most frequently diagnosed species, is known to cause numerous clinical syndromes in both immunocompetent and immunocompromised patients. In healthy individuals, the infection is most commonly manifested as the so-called cat scratch disease.

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Acute diarrhea in infants and toddlers is frequent. Especially severe dehydration increases the risk of mortality in these children. In the therapy for uncomplicated diarrhea (dehydration no more than 9% of body weight loss) it is possible to use oral rehydration solutions (ORS).

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