Publications by authors named "D Barry Kahan"

Bacterial microcompartments (BMCs) are prokaryotic organelles that consist of a protein shell which sequesters metabolic reactions in its interior. While most of the substrates and products are relatively small and can permeate the shell, many of the encapsulated enzymes require cofactors that must be regenerated inside. We have analyzed the occurrence of an enzyme previously assigned as a cobalamin (vitamin B) reductase and, curiously, found it in many unrelated BMC types that do not employ B cofactors.

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Bacterial microcompartments (BMCs) are prokaryotic organelles that consist of a protein shell which sequesters metabolic reactions in its interior. While most of the substrates and products are relatively small and can permeate the shell, many of the encapsulated enzymes require cofactors that must be regenerated inside. We have analyzed the occurrence of an enzyme previously assigned as a cobalamin (vitamin B) reductase and, curiously, found it in many unrelated BMC types that do not employ B cofactors.

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Article Synopsis
  • * Researchers utilized hydrogen-deuterium exchange/mass spectrometry to explore how Pab1's structure changes under stress, revealing that its RNA recognition motifs (RRMs) partially unfold and interact differently depending on the type of stress.
  • * The study identifies a process called sequential activation, where RRMs activate at specific temperatures, enabling Pab1 to form condensates through interactions driven by thermodynamic properties, highlighting a general mechanism for stress-response in proteins.
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Background: Physical inactivity prevalence estimates for youth and adults have been published on a global scale and for various geographical and geopolitical permutations. Only one such study has presented estimates for adults in Muslim countries, and it is nearly 10 years old. I conducted an update of this study by incorporating newer data, refining methods, and including youth estimates.

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Knowledge of the interior structure and atmosphere of Mars is essential to understanding how the planet has formed and evolved. A major obstacle to investigations of planetary interiors, however, is that they are not directly accessible. Most of the geophysical data provide global information that cannot be separated into contributions from the core, the mantle and the crust.

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