Publications by authors named "D Bardana"
Background: Essential amino acid (EAA) and omega-3 fatty acid ingestion independently attenuate leg skeletal muscle disuse atrophy in uninjured persons. However, no data exist regarding the effectiveness of combined EAA and omega-3 fatty acid ingestion to mitigate skeletal muscle disuse atrophy in response to anterior cruciate ligament reconstruction (ACLR) surgery. This pilot trial will explore the feasibility of recruitment and retention of ACLR outpatients from a single center across 18 months to consume either a combination of omega-3 fatty acids and EAAs, or a placebo control, for 4 weeks before and 2 weeks after surgery.
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- T1 mapping and Quantitative Susceptibility Mapping (QSM) are being studied as methods to measure changes in knee osteoarthritis, focusing on their effectiveness in analysis of articular cartilage.* -
- The study involved 20 healthy participants who underwent MRI with different spin lock times, aiming to assess how these combinations impact T1 estimation and correlate with QSM data.* -
- Results showed longer T1 times with higher spin lock periods and noted significant depth-specific differences in both T1 and QSM, suggesting these methods together can enhance the understanding of cartilage microstructure changes.*
Objectives: While substantial progress has been made in engineering cartilaginous constructs for animal models, further research is needed to translate these methodologies for human applications. Evidence suggests that cultured autologous chondrocytes undergo changes in phenotype and gene expression, thereby affecting their proliferation and differentiation capacity. This study was designed to evaluate the expression of chondrogenic markers in cultured human articular chondrocytes from passages 3 (P3) and 7 (P7), beyond the current clinical recommendation of P3.
View Article and Find Full Text PDFPurpose: To determine whether the addition of lateral extra-articular tenodesis (LET) to anterior cruciate ligament reconstruction (ACLR) would improve return-to-sport (RTS) rates in young, active patients who play high-risk sports.
Methods: This multicenter randomized controlled trial compared standard hamstring tendon ACLR with combined ACLR and LET using a strip of the iliotibial band (modified Lemaire technique). Patients aged 25 years or younger with an anterior cruciate ligament-deficient knee were included.