Publications by authors named "D Balasubramaniam"
Article Synopsis
- β-Lactams are the most commonly reported antibiotics linked to allergic reactions, with prior studies indicating higher rates of penicillin allergies in females.
- This systematic review aimed to analyze sex- and gender-based differences in immediate β-lactam allergy prevalence by reviewing studies from multiple databases over a decade.
- The results revealed no overall difference in allergy prevalence between genders but indicated a higher risk of allergy in females during oral challenges, possibly due to biological factors and increased healthcare utilization among women.
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.
Proc Natl Acad Sci U S A
April 2024
Article Synopsis
- Apolipoprotein AV (APOA5) helps lower fat levels (triglycerides) in the blood by stopping another protein complex (ANGPTL3/8) from interfering with lipoprotein lipase (LPL), which breaks down fats.
- Researchers found that a mutation in APOA5 leads to higher triglyceride levels, meaning certain parts of the protein are needed to perform its job well.
- Experiments with mice showed that the normal version of APOA5 worked to reduce triglyceride levels, while a modified version without important parts didn’t, highlighting those parts' key role in keeping fat levels in check.
A patient in his late 30s presented with issues of retrosternal chest pain and palpitations. He had sustained a splinter injury to the left hemithorax a year ago for which he had been managed with a tube thoracostomy. During subsequent evaluations, he was found to have atrial fibrillations and a CT angiography revealed an arch of the aorta pseudoaneurysm with a fistulous communication with the innominate vein, which being a rare condition has no established treatment protocols.
View Article and Find Full Text PDFPurpose: To report a case of oculocardiac reflex following penetrating orbital injury with entrapment of extraocular muscle secondary to a retained orbital foreign body.
Observation: A 19-year-old man with no known comorbidities presented with a foreign object in his right orbit following a motor vehicle accident. Visual acuity was 20/20 bilaterally with positive relative afferent pupillary defect for the right eye.
Clinical Presentation of Schnitzler's Syndrome: A Rare Autoimmune Disease.
J Investig Med High Impact Case Rep
December 2023
Article Synopsis
- - Schnitzler's Syndrome (SS) is a rare, late-onset autoinflammatory disorder characterized by chronic urticaria and a specific type of antibody (monoclonal IgM-kappa), along with symptoms like joint pain and recurrent fevers.
- - Diagnosis requires meeting two major criteria (chronic urticaria and monoclonal IgM) plus at least two minor criteria, with early detection being crucial due to a 15-20% risk of related cancers.
- - A case study of a 39-year-old female highlights the challenges in diagnosing SS; after ineffective treatments, she was successfully managed with an IL-1 inhibitor, illustrating the need for awareness of this rare condition in clinical practice.