Publications by authors named "D B Vigneron"
Tumor acidosis is one of the hallmarks indicating the initiation and progression of various cancers. Here, we present a protocol for preparing a hyperpolarized (HP) C-bicarbonate tissue pH MRI imaging contrast agent to detect aggressive tumors. We describe the steps for the formulation and polarization of a precursor molecule C-glycerol carbonate (C-GLC), the post-dissolution reaction, and converting HP C-GLC to an injectable HP C-bicarbonate solution.
View Article and Find Full Text PDFHyperpolarized (HP) C MRI has shown promise as a valuable modality for measurements of metabolism and is currently in human trials at 15 research sites worldwide. With this growth it is important to adopt standardized data storage practices as it will allow sites to meaningfully compare data. In this paper we (1) describe data that we believe should be stored and (2) demonstrate pipelines and methods that utilize the Digital Imaging and Communications in Medicine (DICOM) standard.
View Article and Find Full Text PDFData Format Standardization and DICOM Integration for Hyperpolarized C MRI.
J Imaging Inform Med
October 2024
Hyperpolarized (HP) C MRI has shown promise as a valuable modality for in vivo measurements of metabolism and is currently in human trials at 15 research sites worldwide. With this growth, it is important to adopt standardized data storage practices as it will allow sites to meaningfully compare data. In this paper, we (1) describe data that we believe should be stored and (2) demonstrate pipelines and methods that utilize the Digital Imaging and Communications in Medicine (DICOM) standard.
View Article and Find Full Text PDFArticle Synopsis
- - MRI with hyperpolarized (HP) C agents allows for the measurement of altered metabolism in various diseases, including cancers and organ diseases, and has seen increased application in human studies over the last decade due to improved preparation methods of HP agents.
- - This paper focuses on the use of [1-C]pyruvate, the most popular HP agent, and is organized into four main sections: agent preparation, MRI system setup, data collection, and analysis, highlighting essential components for effective studies.
- - The findings come from the "HP C MRI Consensus Group" and aim to provide a comprehensive guide for best practices, addressing both successful studies and existing gaps, while fostering future advancements in metabolic imaging.
Purpose: To use the hepatocyte-specific gadolinium-based contrast agent gadoxetate combined with hyperpolarized (HP) [1- C]pyruvate MRI to selectively suppress metabolic signals from normal hepatocytes while preserving the signals arising from tumors.
Methods: Simulations were performed to determine the expected changes in HP C MR signal in liver and tumor under the influence of gadoxetate. CC531 colon cancer cells were implanted into the livers of five Wag/Rij rats.