Publications by authors named "D B Rye"
Article Synopsis
- The study aimed to compare the effectiveness of modafinil versus amphetamine-dextroamphetamine in treating narcolepsy type 2 and idiopathic hypersomnia through a randomized, blinded trial involving 44 adults over 12 weeks.
- Results showed that while modafinil improved sleepiness levels (5.0 points on the Epworth scale) more than amphetamine-dextroamphetamine (4.4 points), the latter was noninferior in several secondary measures of symptoms and disease severity.
- Adverse effects were more prevalent with modafinil, including higher rates of anxiety, while amphetamine-dextroamphetamine showed less dropouts due to adverse events, suggesting implications for treatment choices in these disorders.
Background: Optimal measurement tools for problematic sleep inertia, common in some central disorders of hypersomnolence (CDH), have not yet been determined. We evaluated the performance of the Sleep Inertia Questionnaire (SIQ) in CDH, and how well it distinguished hypersomnolent groups from controls, and IH (idiopathic hypersomnia) from narcolepsy type 1 (NT1).
Methods: This prospective, bi-centric study included 63 control, 84 IH, 16 NT1, 18 narcolepsy type 2 (NT2), and 88 subjective excessive daytime sleepiness (sEDS) participants, using ICSD-3 criteria.
Article Synopsis
- Restless legs syndrome (RLS) affects nearly 10% of older adults, but many face delays in diagnosis and treatment.
- A large-scale genetic study identified 164 risk loci for RLS, enhancing our understanding of its genetic basis and showing similarities in genetic predispositions between sexes.
- Findings suggest potential drug targets, a relationship between RLS and diabetes, and highlight the effectiveness of machine learning in predicting RLS risk using genetic and other data.
Article Synopsis
- Essential tremor (ET) is a common neurological disorder, but its biological causes are still not well understood.
- A comprehensive study involving over 16,000 ET cases identified 12 genetic variants linked to the disorder, suggesting several potential causal genes, including CA3 and CPLX1.
- The findings also reveal associations between ET and other conditions like Parkinson's disease, depression, and anxiety, which could lead to new therapeutic targets for treatment.
Unlabelled: Restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) have been variably implicated in risk for cardiovascular disease (CVD), but there is lack of consensus on these relationships. We sought to assess subclinical CVD measures and RLS/PLMS in a large cohort to further evaluate these associations. The Emory Center for Health Discovery and Well Being cohort is composed of employed adults, with subclinical CVD measures including endothelial function (flow-mediated vasodilation), microvascular function (reactive hyperemia index, RHI), arterial stiffness (pulse wave velocity and augmentation index), and carotid intima-media thickness (cIMT).
View Article and Find Full Text PDF