Publications by authors named "D B Quelch"

Introduction: Alcohol withdrawal is typically managed using benzodiazepines. However, modulation of both γ-aminobutyric acid-A and N-methyl-d-aspartate-receptors through ethanol provision may provide an alternative management strategy. This systematic review critically analyses the evidence surrounding the use of oral or intravenous ethanol for the management of alcohol withdrawal syndrome.

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There is an increasing awareness of the link between chronic alcohol consumption and the development of cognitive, behavioural and functional deficits. Currently, preventative strategies are limited and require engagement in dedicated long-term rehabilitation and sobriety services, the availability of which is low. The acute alcohol withdrawal syndrome is an episode of neurochemical imbalance leading to autonomic dysregulation, increased seizure risk and cognitive disorientation.

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Introduction: Alcohol dependence is a global issue with many negative consequences, including alcohol-related brain damage (ARBD). Assessment of the sociodemographic and cognitive characteristics of individuals with confirmed or suspected ARBD presenting to alcohol services warrants further investigation.

Methods: This study retrospectively examined rates of cognitive impairment using Montreal Cognitive Assessment (MoCA) data from 300 adults who visited three alcohol support services.

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Article Synopsis
  • A study was conducted to evaluate the use of oral ethanol as an alternative to benzodiazepines for managing alcohol withdrawal syndrome in patients within a UK health service setting.
  • The research included a retrospective review of patients treated with either ethanol or benzodiazepines, focusing on those at high risk for severe withdrawal symptoms such as delirium tremens.
  • Results indicated that patients managed with ethanol had a significantly lower likelihood of hospital admission, suggesting that oral ethanol could be a viable treatment option during alcohol withdrawal management.
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