Publications by authors named "D B McMahon"
Article Synopsis
- - The study aimed to find the best presentation levels for the NU-6 ordered-by-difficulty (OBD) word lists to maximize listeners' word recognition scores (WRS) while using a shorter testing approach.
- - Researchers tested varying presentation levels for 34 adults (with and without hearing loss) and found that the starting level often didn't achieve the highest WRS, needing more than 10 words.
- - The findings suggest using a presentation level of at least 30-40 dB SL above the hearing threshold at 2000 Hz, with a minimum of 35 dB HL, or alternatively using UCL-5 if higher levels aren’t achievable.
Objectives: The objective of our study was to benchmark the incidence and severity of lorlatinib-related weight gain and dyslipidaemia in a real-world context, to guide future therapeutic strategies to mitigate these toxicities.
Methods: We conducted a retrospective, observational analysis of patients with ALK and ROS1-positive NSCLC at a single institution in the UK who were commenced on lorlatinib from 11/2016 to 11/2022. Non-small cell lung cancer (NSCLC) patients prescribed lorlatinib were identified through institutional electronic pharmacy records.
Background: Axial spondyloarthritis (AxSpA) is a chronic rheumatic disease characterized by spine inflammation, abnormal bone growth, and paradoxically osteoporosis and vertebral fractures. The pathogenesis of skeletal deficits in this disease is poorly understood.
Purpose: We sought to evaluate volumetric bone mineral density (vBMD) and bone microarchitecture in patients with AxSpA and to identify disease-related factors associated with skeletal abnormalities.
Article Synopsis
- Focused ultrasound (FUS) combined with microbubble (MB) exposure shows promise for targeted drug delivery to the brain, but further refinement for large-scale clinical applications is needed.
- Research involving rabbits demonstrated that continuous manual agitation of MBs during infusion improved blood-brain barrier (BBB) permeability more than gravity drip methods, with key sonication parameters influencing the outcome significantly.
- Overall, the study found that while enhancing BBB permeability, the risk of tissue damage remained low, indicating potential for safer and effective clinical protocols for this technique.