The Gram-positive bacterium survives in environments ranging from the soil to the cytosol of infected host cells. Key to intracellular survival is the activation of PrfA, a transcriptional regulator that is required for the expression of multiple bacterial virulence factors. Mutations that constitutively activate ( mutations) result in high-level expression of multiple bacterial virulence factors as well as the physiological adaptation of for optimal replication within host cells.
View Article and Find Full Text PDFThis article draws on qualitative and quantitative research to examine the relationship between the consumption of khat, symptoms of depression and anxiety and the experience of time among young men in urban Ethiopia. Young men claim that khat, a mild stimulant, both causes and alleviates symptoms of depression and anxiety. However, our quantitative data indicate that there is not a direct relationship between khat and symptoms of depression and anxiety.
View Article and Find Full Text PDFCochrane Database Syst Rev
August 2011
Background: Brief interventions involve a time-limited intervention focusing on changing behaviour. They are often motivational in nature using counselling skills to encourage a reduction in alcohol consumption.
Objectives: To determine whether brief interventions reduce alcohol consumption and improve outcomes for heavy alcohol users admitted to general hospital inpatient units.
Purpose: To organize the properties of safety culture addressed by many studies and to develop a conceptual culture of safety model.
Design And Methods: A comprehensive review of the culture of safety literature within the U.S.