Geometric preprocessing for measurements of comet 67P acquired by Rosetta's Visible and InfraRed Thermal Imaging Spectrometer, Mapping channel (VIRTIS-M).

Comet 67P/Churyumov-Gerasimenko (hereafter 67P) was the primary target of ESA's Rosetta mission. Hyperspectral images acquired by the Mapping channel of the Visible and InfraRed Thermal Imaging Spectrometer aboard Rosetta can be used to derive physical and compositional surface properties by detailed spectrophotometric analyses. This calls for a precise spatial co-registration between measurements and geometry information.

Synapses learn to utilize stochastic pre-synaptic release for the prediction of postsynaptic dynamics.

Synapses in the brain are highly noisy, which leads to a large trial-by-trial variability. Given how costly synapses are in terms of energy consumption these high levels of noise are surprising. Here we propose that synapses use noise to represent uncertainties about the somatic activity of the postsynaptic neuron.

Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant .

is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates.

Qualitative Analysis of Inquiries Received by FDA Regarding Conduct of Clinical Trials during the Covid-19 Public Health Emergency.

Background: This report describes the U.S. Food and Drug Administration (FDA) experience in establishing a dedicated mailbox, and in publishing related guidance, to address concerns among interested parties regarding the conduct of clinical trials during the COVID-19 public health emergency (PHE).