Publications by authors named "D B Jennings"
In a recent Viewpoint article (. 2024;81:789‒90), Okubadejo et al. raised concerns regarding two recent proposals for biological definitions and staging systems for synucleinopathies (the Neuronal Synuclein Disease Integrated Staging System and SynNeurGe system).
View Article and Find Full Text PDFBackground: Limited research has compared the relative risks and benefits different statins have after heart transplantation (HT).
Method: We hypothesize that higher statin intensity is associated with a smaller degree of allograft intimal thickening on intravascular ultrasound (IVUS) at 1-year post-HT. Allograft intima-media thickness (IMT) on the first annual IVUS was retrospectively compared in patients initiated on a low-intensity statin (pravastatin 20 mg daily) versus moderate-intensity statin (atorvastatin 20 mg daily) post-HT.
Exsolution reactions enable the synthesis of oxide-supported metal nanoparticles, which are desirable as catalysts in green energy conversion technologies. It is crucial to precisely tailor the nanoparticle characteristics to optimize the catalysts' functionality, and to maintain the catalytic performance under operation conditions. We use chemical (co)-doping to modify the defect chemistry of exsolution-active perovskite oxides and examine its influence on the mass transfer kinetics of Ni dopants towards the oxide surface and on the subsequent coalescence behavior of the exsolved nanoparticles during a continuous thermal reduction treatment.
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- The study aims to evaluate how effectively the thickness of different macular retinal layers can differentiate glaucomatous eyes and glaucoma suspects from healthy eyes using optical coherence tomography (OCT).
- The findings reveal that the nerve fiber layer (NFL) and ganglion cell layer (GCL) have the best diagnostic accuracy, with the ganglion cell complex (GCC) performing similarly, while the inner plexiform layer (IPL) is less effective. The combination of NFL or GCL yields the highest sensitivity and overall diagnostic performance.
- The results underscore the necessity of assessing individual retinal layers rather than relying solely on combined metrics, as the best-performing layers can vary based on the specific area of the retina
The Neuronal alpha-Synuclein Disease (NSD) biological definition and Integrated Staging System (NSD-ISS) provide a research framework to identify individuals with Lewy body pathology and stage them based on underlying biology and increasing degree of functional impairment. Utilizing data from the PPMI, PASADENA, and SPARK studies, we developed and applied biologic and clinical data-informed definitions for the NSD-ISS across the disease continuum. Individuals enrolled as Parkinson's disease, Prodromal, or Healthy Controls were defined and staged based on biological, clinical, and functional anchors at baseline.
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