Electrolyte engineering via non-fluorinated solvent for high-performance lithium metal batteries.

Lithium metal batteries (LMBs) employing high-voltage cathode present a promising pathway toward high-energy-density energy storage systems. However, critical challenges have hindered their practical application, including lithium dendrite proliferation, unstable solid-electrolyte interphase (SEI), and limited oxidative stability of conventional 1,2-dimethoxyethane (DME)-based electrolytes. Herein, we rationally design a siloxane-based electrolyte system featuring enhanced oxidative stability through solvent molecular engineering.

Potential drivers of pocilloporid coral extirpations in Singapore.

The reason why four out of five historically recorded pocilloporid species in Singapore went extinct remains unclear. However, potential causes include urbanization-related stressors such as sedimentation and low light. In this study, we conducted two ex-situ experiments to examine the effects of light limitation and sediment load on the survival and health of two extirpated (Stylophora pistillata, and Seriatopora hystrix), one extant (Pocillopora acuta), and one regional (Pocillopora meandrina) pocilloporid species.

Temporal trends, clinical characteristics and prognostic factors analysis of infective endocarditis: a multicenter ambispective cohort study in China.

Background: The epidemiological and clinical characteristics of infective endocarditis (IE) in mainland China, particularly following the COVID-19 pandemic, remain insufficiently understood. This study aims to examine temporal trends, clinical features, and factors influencing in-hospital mortality of IE in northern China from 2019 to 2023.

Methods: This multicenter, retrospective study included 961 patients diagnosed with IE between 2019 and 2023 across hospitals in Henan, Shandong, and Tianjin.

Role of DNMT3a Expression and Nuclear Translocation under ELAVL1 mediation for Dendritic Cell Function and Th17/Treg Balance in COPD.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The DNA methyltransferase DNMT3a has been implicated in COPD, however its upstream regulation and downstream mechanisms remain unclear.

Methods: Relative mRNA and protein levels of indicated genes in lung tissues and dendritic cells (DCs) were tested via qRT-PCR and western blot, respectively.

Yi-qi-yang-yin decoction ameliorates diabetic retinopathy: New and comprehensive evidence from network pharmacology, machine learning, molecular docking and molecular biology experiment.

Yi-Qi-Yang-Yin Decoction (YQYY), a traditional Chinese medicine (TCM) formula, has been used to treat diabetic retinopathy (DR), yet its precise mechanisms of action remain poorly understood. In this study, two distinct diabetic models, namely spontaneous type 2 diabetic db/db mice and streptozotocin (STZ)-induced type 1 diabetic rats, were employed to assess the efficacy of YQYY in ameliorating DR. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was employed to identify the chemical composition of YQYY in mouse serum.