Publications by authors named "D B Handel"

Article Synopsis
  • The study assessed the safety and effectiveness of live-jslm (RBL; REBYOTA), the first FDA-approved treatment for preventing recurrent Clostridioides difficile infections (rCDI) in adults after standard antibiotic therapy.
  • Participants included 793 adults with rCDI, with RBL administered within 24-72 hours post-antibiotics, focusing on treatment-emergent adverse events (TEAEs) and treatment success at two intervals: 8 weeks and 6 months.
  • Results showed that RBL was generally safe, with 47.3% experiencing mild to moderate gastrointestinal TEAEs, and 73.8% of participants achieving treatment success at 8 weeks, with a 91% sustained response rate at
View Article and Find Full Text PDF

Recent attention to the causal identification of spending impacts provides improved estimates of spending outcomes in a variety of circumstances, but the estimates are substantially different across studies. Half of the variation in estimated funding impact on test scores and over three-quarters of the variation of impacts on school attainment reflect differences in the true parameters across study contexts. Unfortunately, inability to describe the circumstances underlying effective school spending impedes any attempts to generalize from the extant results to new policy situations.

View Article and Find Full Text PDF

When cure is not possible, suffering often takes form as pain and distressing symptoms, death anxiety, existential distress, and meaninglessness. This paper describes important elements connecting palliative care principles with hypnotic approaches designed to provide support, palliate symptoms, foster hope, and address existential and spiritual distress. We offer a developmental process for and examples of hypnotic suggestions customized to simultaneously ameliorate physical symptoms and address profound distress arising from physical, social, psychological, existential, and spiritual challenges commonly encountered in terminal illness.

View Article and Find Full Text PDF

Goals: We investigated if increasing the colonoscopy screening interval from 10 to 15 years would increase provider preferences for colonoscopy as a screening test. We further examined whether having colonoscopy performed at a 15-year interval by an endoscopist with a high adenoma detection rate would influence preferences.

Background: Colonoscopy is recommended every 10 years in average risk individuals without polyps for colorectal cancer (CRC) screening.

View Article and Find Full Text PDF

We report the case of a 71-year-old male with Crohn's disease, shortness of breath, and chest pain that highlights cardiac involvement in inflammatory bowel disease and the role of point-of-care ultrasonography using an alternate cardiac ultrasound window in making the diagnosis of Crohn's pericarditis. The role of ultrasonography in diagnosis and management of inflammatory bowel disease focuses primarily on intestinal pathology. Cardiac involvement is a rare but clinically impactful extraintestinal manifestation, the diagnosis of which benefits from ultrasonography if the clinician performing and interpreting the exam is aware of the possibility and understands the potential value of whole-body ultrasonography as part of a physical exam.

View Article and Find Full Text PDF