Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors.

Arginase has long been a target of interest in immuno-oncology, but discovering an orally bioavailable inhibitor is severely constrained by the requisite boronic acid pharmacophore. We began our drug discovery campaign by building off the β-position of the literature inhibitor ABH (). A divergent synthesis with an Ireland-Claisen rearrangement as the key step allowed access to numerous compounds, some of which we crystallized in the active site of arginase 2.

Reducing outpatient gastrostomy tube complications.

Objective: To monitor the effectiveness of a multidisciplinary education protocol for gastrostomy tube (GT) use and care for patients to reduce complications postplacement.

Methods: Baseline assessment included a preintervention/intervention design through quantitative measures to determine reduction in the number of GT complications postprocedure following implementation of a patient education protocol for 16 patients in the study.

Intervention: A multidisciplinary approach was used in protocol development for standardizing patient education.

Effect of Ar(3p4p; 2p)+M → Ar(3p4s; 1s)+M branching ratio on optically pumped rare gas laser performance.

Optically pumped rare gas laser performance is analyzed as a function of the Ar(3p4p; 2p) + M → Ar(3p4s; 1s) + M branching ratios. Due to the uncertainty in the branching ratios, a sensitivity study is performed to determine the effect on output and absorbed pump laser intensities. The analysis is performed using a radio frequency dielectric barrier discharge as the source of metastable production for a variety of Argon in Helium mixtures over pressures ranging from 200 to 500 Torr.

MITIGATING COGNITIVE BIASES IN RISK IDENTIFICATION: Practitioner Checklist for the AEROSPACE SECTOR.

This research contributes an operational checklist for mitigating cognitive biases in the aerospace sector risk management process. The includes steps for grounding the risk identification and evaluation activities in past project experiences through historical data, and emphasizes the importance of incorporating multiple methods and perspectives to guard against optimism and a singular project instantiation-focused view. The authors developed a survey to elicit subject matter expert judgment on the value of the checklist to support its use in government and industry as a risk management tool.