Publications by authors named "D B Einstein"
This study evaluated a classroom program to address Intolerance of uncertainty (IU) in secondary school students in Australia. IU is a transdiagnostic vulnerability factor for a range of psychological difficulties. A universal classroom program aimed to increase student understanding of feelings of uncertainty and explored socioemotional factors that could influence behaviors when facing uncertainty.
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- Xp11 translocation renal cell carcinoma (tRCC) is a rare cancer that mostly affects females and is caused by a fusion of the TFE3 gene on chromosome X with other genes.
- The study explores how TFE3 fusions occur through rearrangements and whether these fusions arise from the active or inactive X chromosomes, shedding light on tRCC's female predominance.
- Findings show that TFE3 fusions are typically due to reciprocal translocations and that specific translocations involving the inactive X chromosome contribute to the higher incidence of tRCC in females, revealing important insights into cancer genetics and sex differences.
Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations found in such diseases. We tested a systems pharmacology-based strategy that suppresses intracellular cAMP and Ca2+ activity via G protein-coupled receptor (GPCR) modulation using tamsulosin, metoprolol, and bromocriptine coadministration.
View Article and Find Full Text PDFAutologous therapeutic tumor-infiltrating lymphocyte (TIL) therapy is a promising strategy to enhance antitumor immunity. Optimization of ex vivo TIL expansion could expand current immunotherapy options. Previous attempts to generate TIL in renal cell carcinoma (RCC) have been technically challenging.
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