Engineering human cerebral organoids to explore mechanisms of arsenic-induced developmental neurotoxicity.

Modeling brain development and function is challenging due to complexity of the organ. Human pluripotent stem cell (PSC)-derived brain-like organoids provide new tools to study the human brain. Compared with traditional in vivo toxicological studies, these 3D models, together with 2D cellular assays, enhance our understanding of the mechanisms of developmental neurotoxicity (DNT) during the early stages of neurogenesis and offer numerous advantages including a rapid, cost-effective approach for understanding compound mechanisms and assessing chemical safety.

Excited electronic states of Na2 and K2: The potential for long-lived "reservoir" states leading to collision induced population inversions.

Potential energy curves (PECs) for the spin-free (ΛS) and spin-orbit (Ω) states associated with the four lowest-lying dissociation channels of Na2 and K2 were calculated at the SA-CASSCF/SO-CASPT2/aug-cc-pwCVQZ-DK level. The PECs of Na2 were consistent with the experimental data and with the FS-CCSD (2,0) calculations, reproducing the double-well and the "shelf" character for some of the potentials of the excited states. For K2, the PECs behaved in a similar way and the spectroscopic parameters for the ground and the excited states are in good agreement with the available experimental values.

Searching for a Job: A Survey of Hand Fellowship Applicants and Current Hand Surgeons.

Background: Core curricula do not include courses on how to find employment after hand fellowships. Little data exists in literature regarding job selection in hand surgery. This study's purpose was to provide information to future hand surgeons on ways of finding a job that meets their expectations and to elucidate factors that should be considered before deciding on a hand practice.

Properties of NoO and YbO.

Bond dissociation energies (BDEs) and spectroscopic parameters for the ground states of YbO and NoO were calculated at the Brueckner doubles (BD(T)) level and for NoO at the coupled cluster CCSD(T) level based on the closed-shell configurations Yb(4f)O(2p) and No(5f)O(2p). For YbO, the BD(T) BDE (3.93 eV) and vibrational frequency (686.

A model of occupational stress to assess impact of COVID-19 on critical care and redeployed nurses: a mixed-methods study.

Objective: To use the job demands-resources model of occupational stress to quantify and explain the impact of working in critical care during the COVID-19 pandemic on nurses and their employing organisation.

Design: Two-phase mixed methods: a cross-sectional survey (January 2021-March 2022), with comparator baseline data from April to October 2018 (critical care nurses only), and semistructured interviews.

Participants: Critical care nurses ( = 461) and nurses redeployed to critical care ( = 200) who worked in the United Kingdom National Health Service (primarily Scotland) between January 2021 and March 2022.