Publications by authors named "D B Destephano"
Article Synopsis
- * A meta-analysis of 6 randomized trials involving 1,204 patients found that alkylating chemotherapy improves progression-free survival (PFS) for IDH-wt tumors when combined with radiotherapy, but shows no significant overall survival (OS) benefit.
- * In contrast, IDH-mutant gliomas benefit significantly from alkylating chemotherapy, with substantial improvements in both PFS and OS, indicating a key difference in treatment effectiveness between the two glioma types
Purpose: Novel agents such as PI3K and mTOR inhibitors (PI3K/mTORi) have expanded treatment options in metastatic breast cancer (MBC). Nevertheless, mortality rates remain disproportionately high for Black patients and patients with lower socioeconomic status. Furthermore, clinical trials for these novel agents lacked diversity, so their toxicity profile in minority populations is uncertain.
View Article and Find Full Text PDFThe COVID-19 pandemic caused widespread disruptions in cancer care. We hypothesized that the greatest disruptions in diagnosis occurred in screen-detected cancers. We identified patients (≥18 years of age) with newly diagnosed cancer from 2019 to 2020 in the US National Cancer Database and calculated the change in proportion of early-stage to late-stage cancers using a weighted linear regression.
View Article and Find Full Text PDFPurpose: Previous comparative effectiveness studies have not demonstrated a benefit of proton beam therapy (PBT) compared with intensity-modulated radiation therapy (IMRT) for prostate cancer. An updated comparison of GI and genitourinary (GU) toxicity is needed.
Methods: We investigated the SEER-Medicare linked database, identifying patients with localized prostate cancer diagnosed from 2010 to 2017.