Publications by authors named "D B Brunner"
Background: A dysregulated stress response, including exaggerated affective reactivity and abnormal hypothalamic-pituitary-adrenal axis responsivity, has been implicated in the etiology, maintenance, and relapse of major depressive disorder (MDD). Among adolescents, discordant affective and physiological stress response profiles have been linked to negative affective outcomes and increased risk for psychopathology. Whether these findings extend to adults with varying degree of MDD risk is unclear, as are possible links to various risk factors.
View Article and Find Full Text PDFUsing proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .
View Article and Find Full Text PDFOverview of the early campaign diagnostics for the SPARC tokamak (invited).
Rev Sci Instrum
October 2024
The SPARC tokamak is a high-field, Bt0 ∼12 T, medium-sized, R0 = 1.85 m, tokamak that is presently under construction in Devens, MA, led by Commonwealth Fusion Systems. It will be used to de-risk the high-field tokamak path to a fusion power plant and demonstrate the commercial viability of fusion energy.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effects of binge drinking on young adults, specifically looking at how acute alcohol intake can lead to cardiac arrhythmias, like atrial fibrillation, known as holiday heart syndrome.
- - A total of 202 volunteers were monitored for 48 hours with ECGs during different phases: before drinking, while drinking, during recovery, and afterward, revealing increased heart rates and arrhythmias tied to alcohol consumption.
- - Findings show that while drinking, participants experienced higher atrial tachycardias and during the recovery phase, notable arrhythmias emerged, highlighting the health risks associated with excessive alcohol intake.
Article Synopsis
- Scientists want to understand how the placebo effect works in people with major depressive disorder (MDD) because it's getting stronger in clinical trials, making it harder to find out if new treatments really work.
- They believe that studying how dopamine (a chemical in the brain related to rewards and pleasure) affects the placebo response could help find out who benefits from treatments and improve mental health care.
- The researchers set up a special clinical trial to explore this idea, using different methods to look at how the brain's reward system might influence the placebo effect in people with depression.