Publications by authors named "D Ayoub"
Purpose: Children with epilepsy are at an increased risk of developing psychiatric comorbidities, which exacerbate the overall disease burden. However, these disorders are often underreported in developing countries. This study, conducted in a developing country, aims to evaluate the frequency of psychiatric disorders and associated factors in a large cohort of children with epilepsy.
View Article and Find Full Text PDFObjective: Previous studies assessing factors associated with drug-resistant epilepsy (DRE) were constrained by their amalgamation of all epilepsy syndromes in their analyses and the absence of uniform criteria for defining DRE. Our objective was to identify predictors of DRE among the four primary childhood epilepsy syndrome groups within a cohort of children with new onset seizures, using the International League Against Epilepsy (ILAE) definition of DRE and the recent classification of epilepsies.
Methods: This is a prospective study of 676 children with new onset seizures initiated on antiseizure medication.
Article Synopsis
- - Metabolic Bone Disease of Infancy (MBDI) is a condition that leads to fragile bones and multiple unexplained fractures, often mistaken for child abuse, with diagnosis reliant on radiographic evidence of healing rickets and specific blood tests.
- - A study analyzing MBDI cases from 2015 to 2021 found that 29% of infants tested had elevated levels of blood 1,25-dihydroxyvitamin D (1,25-DiOHVD), which is associated with increased bone fragility; the average age for presenting with fractures was 11 weeks.
- - The findings suggest that elevated 1,25-DiOHVD levels in infants with MBDI indicate significant bone frag
Background: Necrotizing pneumonia (NP) is a rare serious complication of community-acquired pneumonia (CAP) in children, which is characterized by a protracted course of the disease and a prolonged hospital stay. This study aimed to assess the role of systemic immune-inflammatory index and systemic inflammatory response index in predicting early lung necrotization in children with CAP.
Methods: This study included all children hospitalized in Pediatric Pulmonology Unit, Tanta University, Egypt, with CAP between the ages of two months and 18 years.
The controlled expression of two or more proteins at a defined and stable ratio remains a substantial challenge, particularly in the bi- and multispecific antibody field. Achieving an optimal ratio of protein subunits can facilitate the assembly of multimeric proteins with high efficiency and minimize the production of by-products. In this study, we propose a solution based on alternative splicing, enabling the expression of a tunable and predefined ratio of two distinct polypeptide chains from the same pre-mRNA under the control of a single promoter.
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