Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase.

Cleavage of transmembrane segments on target proteins by the aspartyl intramembrane protease signal peptide peptidase (SPP, encoded by HM13) has been linked to immunity, viral infection and protein quality control. How SPP recognizes its various substrates and specifies their fate remains elusive. Here, we identify the lanosterol demethylase CYP51A1 as an SPP substrate and show that SPP-catalysed cleavage triggers CYP51A1 clearance by endoplasmic reticulum-associated degradation (ERAD).

The Effect of Forgiveness and Resilience on Anxiety, Depression and Stress in Nursing Students.

To examine the effects of forgiveness and resilience on anxiety, depression, and stress in nursing students. Cross-sectional correlational study. The convinient sample of the study consisted of 383 nursing students.

The relationship between resilience and solution-oriented thinking in nursing students.

Objective: This study aimed to determine the relationship between resilience and solution-oriented thinking in nursing students.

Background: Although resilience seems to be related with solution-oriented thinking in nursing students, there are only a few studies investigating these two variables in the literature.

Design: This is a cross-sectional survey study.

New Ibuprofen Cystamine Salts With Improved Solubility and Anti-Inflammatory Effect.

Two novel ibuprofen cystamine salts (IBU-CYS 1 and IBU-CYS 2) are synthesized by coupling the anion of ibuprofen with cystamine dihydrochloride in 1 : 1 and 2 : 1 ratio to improve the solubility and bioavailability of ibuprofen. The salts are characterized by H NMR, FT-IR and UV-Vis spectroscopy, differential scanning calorimetry (DSC), thermogravimetry (TGA, DTA) and X-ray diffraction measurements. IBU-CYS 1 and IBU-CYS 2 show higher solubility (6.