Publications by authors named "D Augusto"

Introduction: In the reconstructive phase of medico-legal human identification, the sex estimation is crucial in the reconstruction of the biological profile and can be applied both in identifying victims of mass disasters and in the autopsy room. Due to the inherent subjectivity associated with traditional methods, artificial intelligence, specifically, convolutional neural networks (CNN) may present a competitive option.

Objectives: This study evaluates the reliability of VGG16 model as an accurate forensic sex prediction algorithm and its performance using orthopantomography (OPGs).

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Objectives: The aim of the present study was to investigate if there are differences in mitigation acute pain following oral surgery procedures within a hospital setting and regarding various medication regimens.

Materials And Methods: A systematic literature search was performed between the years 2013 and 2023, including the databases PUBMED, Cochrane and Scopus, to identify the clinical trials investigating the prescription of non-steroidal (NSAID's) anti-inflammatory drugs before or after an oral surgery. A meta-analysis with meta-regression model was employed on the primary and secondary outcomes, such as pain, swelling and trismus.

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Article Synopsis
  • The human major histocompatibility complex (MHC) has high genetic diversity, making traditional reference-based alignment methods for DNA sequence assembly less effective.
  • MHConstructor is a new tool that uses a short-read, de novo assembly algorithm specifically for MHC data, allowing for improved assembly in large population studies.
  • This pipeline is unique in offering a reproducible, alignment-free method for analyzing MHC sequences, making it more accessible for researchers.
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CD8+ T cells are the dominant lymphocyte population in multiple sclerosis (MS) lesions where they are highly clonally expanded. The clonal identity, function, and antigen specificity of CD8+ T cells in MS are not well understood. Here we report a comprehensive single-cell RNA-seq and T cell receptor (TCR)-seq analysis of the cerebrospinal fluid (CSF) and blood from a cohort of treatment-naïve MS patients and control participants.

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Article Synopsis
  • The study focuses on understanding how dental pulp changes after death to help estimate the post-mortem interval (PMI), particularly beyond the first week, using both qualitative and quantitative analysis of dental histomorphology.
  • A total of 27 sound teeth from 16 healthy patients were analyzed, considering various time intervals post-tooth extraction to simulate time elapsed since death.
  • Initial findings indicate that dental pulp shows signs of degeneration as soon as 7 hours post-mortem, though the specific histological changes exhibit significant variability.
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