Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice.

Immobilization-associated muscle atrophy and weakness appear to be driven in part by oxidative stress. Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) is a critical redox rheostat that regulates oxidative stress responses, and its deletion is known to accelerate muscle atrophy and weakness during aging (sarcopenia) or denervation. Conversely, pharmacologic activation of NRF2 extends mouse lifespan and attenuates sarcopenia.

Cost-effectiveness of atraumatic restorative treatment combined with the Hall Technique for managing dental caries in remote Indigenous children.

Background: Indigenous children in remote Australia face significant disparities in oral health and have limited access to dental care. This study evaluated the cost-effectiveness of Atraumatic Restorative Treatment combined with the Hall Technique (ART-HT) compared to usual care.

Methods: A cost-effectiveness analysis using data from a 1-year ART-HT trial estimated dental caries status and costs from a health-provider perspective.

Detection of cognitive impairment, dementia and associated risk factors among Aboriginal and Torres Strait Islander peoples: Retrospective baseline audit results from a stepped-wedge cluster-randomised controlled trial.

Objective: Aboriginal and Torres Strait Islander peoples experience high rates of dementia, cognitive impairment not dementia (CIND) and associated risk factors. The objective of this paper is to outline baseline audit results of documented dementia, CIND and associated risk factors in patients attending Aboriginal Community-Controlled Health Organisations (ACCHOs).

Methods: Twelve ACCHOs in urban, regional and remote locations across Queensland, New South Wales, Victoria and Western Australia participated in the study.

Comparison of continuous non-invasive blood pressure measurement using Vitalstream™ to invasive Intraarterial pressure in pediatric surgery.

Background: Accurate blood pressure monitoring is essential in many clinical scenarios for adults and children and, when continuous measurement is critical, necessitates the insertion of an arterial line. A novel continuous non-invasive arterial pressure monitoring device using a pulse contour algorithm (Pulse Decomposition Analysis), Vitalstream™, is approved by the United States Food and Drug Administration for use in adults. In this study the performance and accuracy of the device compared to intraarterial blood pressure monitoring were assessed in children ages 2-17 undergoing major surgeries.