Synthesis, photo-physicochemical and biological properties of novel tetrahydropyrimidone-substituted metallo-phthalocyanines.

In this study, new peripherally substituted symmetric zinc and magnesium phthalocyanines (4 and 5) were successfully prepared by cyclotetramerization of the tetrahydropyrimidone (THPM)-linked phthalonitrile 3. The identity of the compounds were confirmed primarily through spectroscopic analysis including NMR, FT-IR, UV-Vis and MALDI-TOF mass spectroscopy. The photophysical and photochemical properties of the synthesized phthalocyanines (Pcs) were examined using UV-Vis absorption and fluorescence emission spectroscopy techniques.

Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.

Mouse embryonic stem cells (ESCs) display pluripotency features characteristic of the inner cell mass of the blastocyst. Mouse embryonic stem cell cultures are highly heterogeneous and include a rare population of cells, which recapitulate characteristics of the 2-cell embryo, referred to as 2-cell-like cells (2CLCs). Whether and how ESC and 2CLC respond to environmental cues has not been fully elucidated.

New AB-type porphyrins with piperidine and morpholine motifs; synthesis and photo-physicochemical and biological properties.

In this study, new unsymmetrical -tetraaryl AB-type porphyrins 1 and 2 were successfully synthesized by the reaction of -bromobenzaldehyde and -hydroxybenzaldehyde with pyrrole in propionic acid. AB-type porphyrin building blocks with hydroxyl functionality (1 and 2) were further used to generate both covalently linked metal free and Zn(II) porphyrins 3-6 having piperidine and morpholine heterocyclic units. These novel compounds were characterized by using H NMR, C NMR, FT-IR and MALDI-TOF spectrophotometry.

Chemo-photodynamic Activity of Silicon Phthalocyanines Bearing Cyclooxygenase Inhibitors on Colorectal Cancer Cell Lines.

Colorectal cancer ranks as the third most lethal cancer worldwide, resulting in over 1 million cases and 900 000 deaths per year. According to population-based studies, administration of long-term non-steroidal anti-inflammatory drugs (NSAIDs) was proven to reduce the risk of a subject developing colorectal cancer. In the present study, the anti-cancer activity of two different NSAIDs, sulindac- () or diclofenac-substituted () asymmetric silicon phthalocyanine derivatives, was evaluated in four different colorectal cancer cell lines bearing various carcinogenic mutations.

Triphenylamine substituted copper and zinc phthalocyanines as alternative hole-transporting materials for solution-processed perovskite solar cells.

In the present study, new peripheral substituted Zn(II) and Cu(II) phthalocyanine derivatives (p-ZnPc and p-CuPc) bearing bulky aromatic triphenylamine groups were synthesized as alternative hole-transporting materials (HTMs). The structures of the new phthalocyanine derivatives (p-ZnPc and p-CuPc) were illuminated by various spectroscopic techniques such as mass spectrometry and H, and C-NMR. After structural analysis, their photophysical properties in solution and the solid phase were examined by UV-Vis absorption and fluorescence spectroscopy.