Small molecule protein assembly modulators with pan-cancer therapeutic efficacy.

Two structurally unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against Mpox virus (formerly known as monkeypox virus) and human immunodeficiency virus (HIV) respectively, were studied for anti-cancer efficacy. Each exhibited apparent pan-cancer cytotoxicity with reasonable pharmacokinetics. Non-toxicity is demonstrated in a non-cancer cell line and in mice at doses achieving drug exposure at active concentrations.

Cutaneous Metastasis From Gallbladder Carcinoma: A Rare Case.

The occurrence of cutaneous metastasis from internal malignancies is relatively rare. Furthermore, cutaneous metastasis from gallbladder carcinoma is an infrequent phenomenon, with only a few reported cases. Here, we report a case of a 45-year-old male with cutaneous metastasis from primary gallbladder carcinoma, initially presenting solely with a scrotal lesion.

Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.

Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, the location of percepts depends on the electrode's location and the percept intensity depends on the stimulation frequency and amplitude. Sensors on a bionic hand can thus be linked to somatotopically appropriate electrodes, and the contact force of each sensor can be used to determine the amplitude of a stimulus.

A comparative study between modified Bishop score and transvaginal sonography to predict successful induction of labor.

Background: Modified Bishop score (MBS) and cervical length determination by transvaginal sonography (TVS) are the two methods for predicting successful vaginal delivery based on pre-induction favourability of the cervix.

Aims And Objectives: This study compared both methods for predicting successful vaginal delivery. The primary objective was to compare the predictive value of MBS and TVS in predicting successful induction of labor.

Factors Associated with Shock at Presentation in Kawasaki Disease Versus Multisystem Inflammatory Syndrome in Children Associated with COVID-19.

Background: While clinical overlap between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) has been evident, information regarding those presenting with shock has been limited. We sought to determine associations with shock within and between diagnosis groups.

Methods: The International KD Registry enrolled contemporaneous patients with either KD or MIS-C from 39 sites in 7 countries from 01/2020 to 01/2023.