Publications by authors named "D Ardissino"
Background: Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI.
Methods: The Italian Genetic Study of Early-Onset Myocardial Infarction is a cohort study enrolling patients with MI before 45 years.
Article Synopsis
- The study investigates which polygenic scores (PGSs) for coronary artery disease (CAD) are most effective in identifying high-risk individuals within the Italian population, highlighting the need for tailored genetic risk assessment tools.
- Using data from two independent Italian cohorts, the researchers analyzed 266 PGSs and found that 49 of them showed significantly different distributions between CAD patients and controls, with PGS003727 being the most accurate.
- The findings suggest that existing European CAD PGSs may not be uniformly applicable across different populations, emphasizing the importance of further validation for clinical use in specific regions like Italy.
Aims: Sudden cardiac death (SCD) is a serious consequence of a myocardial infarction (MI), but identifying patients at risk of developing SCD remains a major clinical challenge, especially in the case of juvenile MI. The aim of this study is to identify predictors of SCD after early-onset MI using long-term follow-up data relating to a large nationwide patient cohort.
Methods And Results: The Italian Genetic Study on Early-onset MI enrolled 2000 patients experiencing a first MI before the age of 45 years, who were followed up for a median of 19.
Incidental discovery of a complex coronary anatomy with multiple rare anomalies.
Eur Heart J Imaging Methods Pract
January 2024
To compare the efficacy of polymer-free drug-eluting stents (PF-DES) versus other stents in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions. A systematic review and meta-analysis were performed to identify pertinent randomized controlled trials. The primary end point was the occurrence of target lesion failure.
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