Dementia Care Practice.

Background: The built environment is increasingly recognized as a valid medical intervention, known to affect mental and social health, which can carry consequences for cognitive function. "Transitional spaces" are indoor/outdoor areas designed to foster connections to the surrounding world and boost well-being including windows, porches, and public parks. Little is known about the space design characteristics that might help improve social and mental health.

Dementia Care Practice.

Background: Lecanemab and other new amyloid-targeting immunotherapies for Alzheimer's disease show great promise but, may also pose significant risk for patients. To facilitate the implementation and monitoring of lecanemab infusions at our tertiary medical center, we convened an interprofessional team. The team created a number of resources including patient handouts and medical documentation templates as well as systems and processes.

Gyrfalcon Prey Abundance and Their Habitat Associations in a Changing Arctic.

Arctic habitats are changing rapidly and altering trophic webs and ecosystem functioning. Understanding how species' abundances and distributions differ among Arctic habitats is important in predicting future species shifts and trophic-web consequences. We aimed to determine the habitat-abundance relationships for three small herbivores on the Seward Peninsula of Alaska, USA by fitting data from 983 point counts (collected during 2019, 2021, and 2022) with N-mixture models that account for imperfect detection.

A generalized objective CT-based method for quantifying articular fracture severity.

A CT-based method for objectively assessing fracture severity was previously developed and validated to address poor reliability in existing subjective fracture classification systems. The method involved quantifying the energy involved in creating a fracture. However, clinical utility of the method was hindered by reliance upon an intact contralateral CT and lengthy analysis time (8-10 h).

Pan-Cancer Insights: A Study of Microbial Metabolite Receptors in Malignancy Dynamics.

Background/objectives: The role of the gut microbiome in cancer biology has become an increasingly prominent area of research, particularly regarding the role of microbial metabolites and their receptors (MMRs). These metabolites, through the various gut-organ axes, have been proven to influence several pathogenetic mechanisms. This study conducted a comprehensive pan-cancer analysis of MMR transcriptomic profiles across twenty-three cancer types, exploring the mechanisms through which they can influence cancer development and progression.