Publications by authors named "D Andrey"
Background: In the context of increasing antimicrobial resistance (AMR), whole-genome sequencing (WGS) of bacteria is considered a highly accurate and comprehensive surveillance method for detecting and tracking the spread of resistant pathogens. Two primary sequencing technologies exist: short-read sequencing (50-300 base pairs) and long-read sequencing (thousands of base pairs). The former, based on Illumina sequencing platforms (ISPs), provides extensive coverage and high accuracy for detecting single nucleotide polymorphisms (SNPs) and small insertions/deletions, but is limited by its read length.
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- Fusobacterium necrophorum is a harmful bacterium that can cause serious infections in the throat, potentially leading to a severe condition called Lemierre's syndrome.
- Researchers studied 70 strains of F. necrophorum, finding two main genetic groups: one linked to localized infections and another more common in cases of severe bacteremia.
- A specific mutation in the lktA gene, along with other identified genetic factors, seems to play a role in the severity of infections, requiring further research to understand their impact on disease development.
Article Synopsis
- - Carbapenem-resistant Enterobacterales are rising in frequency, leading to hospital-acquired infections like postoperative mediastinitis.
- - A case study details a 13-month-old boy with DiGeorge syndrome who developed this infection from an Escherichia coli strain producing NDM-1 carbapenemase.
- - The boy was treated successfully with surgery and a combination of antibiotics over 6 weeks, showing positive recovery without any relapses in a follow-up period of 10 weeks.
Multi-resistant Enterobacterales (MRE) are on the increase worldwide, with the main mechanism of resistance acquisition being horizontal transfer of plasmids coding for extended-spectrum betalactamase and/or carbapenemase. Low- and middle-income countries are the most affected, but surveillance in low-endemicity countries, such as Switzerland, is essential. International travel is one of the sources of MRE dissemination in the community, with the main risk factors for acquiring MRE being a stay in South or Southeast Asia and the use of antibiotics during travel.
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- * Researchers tested various antibiotic combinations in the lab and confirmed the effectiveness of ceftazidime/avibactam with meropenem against 26 KPC-Kp strains, showing strong synergistic effects.
- * In animal trials, this combination not only reduced bacterial loads but also helped prevent the development of antibiotic resistance mutations, suggesting it could be a promising treatment option.