Publications by authors named "D Aloi"
Purpose: Treatment delays due to the COVID-19 pandemic in uveal melanoma (UM) patients have led to an increased rate of enucleations in Europe. The impact of multiple COVID-19 lockdowns on UM management has not been assessed in France. The goal of this study was to assess whether delayed diagnosis could have led to more advanced stages and thus a higher rate of enucleations.
View Article and Find Full Text PDFPurpose: Patients with large uveal melanomas are at major risk of liver metastases. Some patients are reluctant to undergo the standard treatment (ie, immediate enucleation). Proton therapy yields 5-year local control rates and eyeball retention of >85% and ≈20% in large uveal melanomas.
View Article and Find Full Text PDFTherapeutic options to restore responsiveness in patients with prolonged disorder of consciousness (PDOC) are limited. We have recently shown that a single session of tDCS over M1 delivered at rest can reduce thalamic self-inhibition during motor command following. Here, we build upon this by exploring whether pairing tDCS with a concurrent passive mobilisation protocol can further influence thalamo-M1 dynamics and whether these changes are enhanced after multiple stimulation sessions.
View Article and Find Full Text PDFArticle Synopsis
- This study compares survival outcomes between salvage total laryngectomy (TL) and primary TL in patients with advanced laryngeal or hypopharyngeal cancer, aiming to identify key predictive factors.
- The analysis included 234 patients and found that five-year overall survival was significantly lower for salvage TL (25%) compared to primary TL (53%), with several factors like tumor site and comorbidity impacting outcomes.
- The findings emphasize that salvage TL leads to worse survival rates, underscoring the importance of carefully selecting patients for larynx preservation and understanding predictive factors that influence treatment decisions.
Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program.
Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses.