Publications by authors named "D Allard"
Immunosuppression by adenosine is an important cancer immune checkpoint. Extracellular adenosine signals through specific receptors and can be transported across the cell membrane through nucleoside transporters. While adenosine receptors are well-known to regulate tumor immunity, the impact of adenosine transporters remains unexplored.
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- Self-reactive T cells in autoimmune diseases can persist and function well without showing typical exhaustion symptoms, despite being exposed to the same antigens over time.
- Research showed that these autoimmune CD4 T cells maintain TCF1 expression even in the absence of infectious signals, which is crucial for their continued function.
- The study also indicated that the Tcf7 gene undergoes specific epigenetic changes during the early stages of autoimmune T cell differentiation, helping to explain why these cells can survive and remain active for longer periods.
Objectives: Worldwide, there is an estimated 40.3 million victims trapped in modern day slavery, including 24.9 million in forced labor and 15.
View Article and Find Full Text PDFInhibition of adenosine A2A receptor (A2AR) is a promising approach for cancer immunotherapy currently evaluated in several clinical trials. We here report that anti-obesogenic and anti-inflammatory functions of A2AR, however, significantly restrain hepatocellular carcinoma (HCC) development. Adora2a deletion in mice triggers obesity, non-alcoholic steatohepatitis (NASH), and systemic inflammation, leading to spontaneous HCC and promoting dimethylbenzyl-anthracene (DMBA)- or diethylnitrosamine (DEN)-induced HCC.
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